Background. Fruits ofMimusops kummel A. DC. (Sapotaceae) are traditionally used for the treatment of diarrhea.Thepresent study\naimed at investigating modes of actions of this fruits for antidiarrheal action to guide future drug development process. Methods.\nFractions of chloroform, n-butanol, and water were obtained from 80% methanol extract, which was prepared by maceration.\nAntidiarrheal activities and the modes of actions were investigated in mice. Results. In castor oil induced diarrheal model, the\nextract delayed onset of diarrhea and reduced number and weight of feces at all tested doses significantly. In this model all fractions\nsignificantly delayed onset of diarrhea at all tested doses. Charcoal meal test showed that the extract and all the fractions produced\na significant antimotility effect at all tested doses. Enteropooling test showed that the extract as well as n-butanol and aqueous\nfractions at all tested doses produced a significant decline in volume and weight of intestinal contents, whereas chloroformfraction\nhad substantial effect only at high dose. Conclusion. This study demonstrated that the extract and solvent fractions produced\nantidiarrheal activities due to dual inhibitory effect, intestinal motility, and fluid secretion, with the aqueous fraction being the\nmost active among fractions in three models.
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